Adding an appropriate amount of hydroxypropyl methylcellulose during the production process of hand sanitizer can effectively thicken it. In addition, Hydroxypropyl Methyl Cellulose is a non-ionic chemical substance that will play an irreplaceable role in the application of other thickeners, such as stronger stability, cold resistance, anticoagulant and electrolyte resistance, better flowability and a smoother brushing sensation. In addition, the use of hydroxypropyl methyl fiber in hand sanitizer has anti irritation properties, making it gentler. At the same time, it has good water retention and film-forming properties on the skin of the hand. Its biggest advantages are safety, non toxicity, and easy biodegradability. Secondly, the addition of HPMC to the hand sanitizer can also improve the foam, provide rich foam, make the hand sanitizer better contact with human hands, and use less hand sanitizer to obtain better cleaning effect.